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The Colorado River toad—a.k.a. the Sonoran Desert toad—is flat and squat. No distinctive markings adorn its swampy olive skin, and while a passerby may remark upon its large size, the toad does little to draw attention to itself. And yet, for an animal so easy to miss or ignore, the amphibian provides a surprising asset for psychonauts: The Colorado River toad is the only animal source of “the God molecule”—5-MeO-DMT.

5-MeO DMT: Sonoran Desert Toad Venom, Synthetic Psychedelic, Plant Medicine, or All Three?

5-MeO-DMT is a potent psychedelic found within the excretion of the Colorado River toad (Bufo alvarius or Incilius alvarius). Although, it’s also present in some plants and can be made synthetically—the latter being the most sustainable way to consume the entheogen. It belongs to a class of chemical compounds called tryptamines, which include psilocybin and DMT (N,N-dimethyltryptamine).

In the United States, the Colorado River toad is one of the most common and controversial sources of 5-MeO-DMT. Its native habitat runs along the southwestern United States and northern Mexico. But, the oldest known uses of 5-MeO-DMT come from South America. The chemical is a natural constituent in Anadenanthera peregrina seeds, which are used to make entheogenic Yopo snuff.

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10 grams, 15 grams, 25 grams, 35 grams

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